I even told them about the Simparica which they dont respond to. I will not be giving him simparica again. Is there hope? Back to the vet and I hope they credit my money. The vet office called simparica hotline to find out if it was safe to give her another one. Stopped meds and he has had 3 more seizures since. We just brought him home from hospital today. However, besides being nervous over the diarrhea, I am petrified about all of these people talking about seizures. March 2016 saw the addition of Simparica, yet another so-called Isoxazoline flea and tick "remedy" and already several dogs have been adversely affected by this new drug. It is recommended to wash your hands after administering this medication. Thanks to its innovative formula, the treatment continues to work for 35 days, providing long-lasting relief from parasites and the diseases they carry. The issues started within 24 hours of the dose and continue. But I noticed that I had to "wake him' several times in only 2 minutes time, but he wasn't sleeping, his eyes were open and I saw them rolling in the back of his head! all my dogs were prescribed and my eldest dog has had a strange reaction hives all over his body, panting, restless started same night he took the pill but has had the product on previous occasions with no side effects but this time he had a that reaction,had to administer meticam for the pain and antihistamines for the hives - he is still not right after 4 days and my other dog louie has always suffered from seizures since a pup vet say possible epilepsy - managed without medication at present and I do always try to avoid medication with him as they always make his seizures worse - I am so angry for not researching this further before .. Use with caution in dogs with a history of seizures or neurologic disorders. The vet and company are in consultation. If she comes out of this I will return to heartworm pills and topical flea and tick meds. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. They had no clue what had happened so again we took him to the er and he checked out fine. I sure hope we don't have ongoing problems. She was terrified and we were too. Hello! So no Addisions. Most of us dog parents use some form of heartworm prevention for our dogs. Please do NOT try Simparica Trio, I went to the Vets office to pick up Dukes Revolution Heart Worm meds, and they talked me into switching to Simparica Trio, we gave Duke his first dosage on March 1st, March 2nd, he would fall down while walking, he would fall down trying to get up, he's NEVER done this before! Glad i held off on the free sample i was given! I am currently in the same situation and we are at day 16 after giving simparica. Side effects are uncommon, but may occur in some cases. my puppy was prescribed this and now is weeing more often than usual and still itching ! The only thing we changed after his checkup if Feb. was his flea and tick treatment. Although these products can and have been. Just wanted to share my experience in case anyone else has similar experience with dog's character changing. Not sure what effects he will continue to have. I am very worried I called the vet they said oops sorry they made a mistake. Today is day three and she is a little better, with fewer episodes of tremor and more often able to walk without falling. Never had them ever and she's only 3 1/2 yrs old. I am so sorry for your loss. Just after the 4th dose he started to collapse at his feeding dishes on the floor, next we raised dishes and he did ok for being shaky but continued to decline to the point where he could not use dishes , and now cant eat or drink. I have 3 other dogs - large breeds that also took 1 dose, but no reaction. Generally, they may instruct you to administer it immediately when you remember and resume monthly dosing. After reading theses comments I started looking into SIMPARICA TRIO. I could never forgive myself. He had his second dose on 3rd July. Simparica is good at killing contagious parasites that cause mange and scabies. Training your dog to follow basic commands builds a positive relationship with her and helps ensure her safety. Simparica and Simparica Trio should be stored at or below 86 F. Brief exposure of Simparica to temperatures up to 104 F are acceptable. Moreover, the safe use of this product has not been evaluated in breeding, pregnant or lactating dogs. All we want to do is take the best care of our animals and trust the people (Vet's) who specialize in this to do what's right for them. Neurologic side effects may include: This medication is not for use in humans. Then he came too . . It's been the worst 2 months. First month, the one threw up, same thing second month. He scratched at them which made it worse. Hi Laura, just wondering what supplements you gave your pup to help and how long it took for her to get back to herself after simparica. This went on for 4 hours. My miniature Dash hound did not pull out. This drug has caused our dog to loose his footing and not eat. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). After realizing that the only thing that we did differently was to give him his first dose of Simperica, my wife began research and came across this conversation. If you need to get rid of parasites, spot-on (the one by a German company is effective enough) will do the job and do it safely. I feel so bad ,my 8weeks cockerspaniel hasnt been the same 24 hours of giving first dose of Simparica trio.My boy has been distressed with lethargic conditions,sleepy and peeing . Let us now look at possible side effects when administering Simparica. Simparica Trio should be given orally once a month at the recommended minimum doses: 0.54 milligrams of sarolaner, 0.011 mlilligrams of moxidectin, and 2.27 milligrams of pyrantel per pound of body weight. I have always been apprehensive about putting my dog on Heartworm / Flea Tick medication because of horror stories, but I thought he's 5 and it will be from the vet and it seems like the responsible thing to do. We received the first dose of this medication from our Vet! We gave our 3.5 month old Aussie pup a dose of Simparica today (vet's prescription), and I did not see the warnings about giving it to dogs under 6 months. I have already had a bad experience with "k9 advantix", so I refuse to buy over the counter drugs for my 13 week old Auggie. When fleas or ticks bite, they are exposed to its FDA-approved ingredient sarolaner, the insecticide, and acaricide that kills parasites fast. Twice I have seen his eyes roll into the back of his head (petti-mal seizure?) My best friend's new puppy has had diarrhea for 14 days after taking one dose of Simparica. I feel like this drug was pushed by my vet tech and veterinarian. I just found these comments and I am feeling terrible. Has anyones dog stopped having seizures when the medication wore off or is this going to be a permanent issue possibly getting worse? I realized it was from the simparica. How can it not be the Simparica that did this to my baby when nothing else changed. A week after I lost her I got COVID and was in the hospital for 20 days. The FDA considers this level to be "very rare". This is still going on weeks later. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. And since then has had diarrhea and loose poop. I am hopeful he will make it through the next few weeks. How common are Simparica side effects? I suppose with any drug, during trials, there will be some who have side effects ranging from negligible to life threatening. now almost exactly two months later, sick again with a fever and stops eating. The day after administering drug he had two incapacitating seizures. I feel so sad for you Camelia. The personality change is what has me most concerned too. He was given fluids, anti-nausea meds, meds to assist with the inflammation of his esophagus. Got a new GS when the old one died. This content shouldnt take the place of advice by your vet. The excerpts below from the manufacturers' Prescribing . Please do NOT use it!! I hope this drug has not caused permanent damage. Omg my girl goes threw incredible itching this has lead to us takeing her to the vet because she gets infected from scratching herself to death. Idk what to do. It is a very traumatic experience that I saw my 1 year old dog go through and now no lo ever here. She probabpy had some in her system (which is quite common, even for well-cated-for puppies), which would explain her diarrhea. After about 35 days he was back to normal. Did you go to the vets or not? He started having skin issues that the vet said were allergic reactions probably due to environmental things. I'm so sorry. Never saw tremors before. So sorry! Now, here we are one month later and I just gave him the second dose about two hours ago. The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. The company's thinking must be the profits outweigh the loses from any lawsuits lost its important to note that the law treats animals as property and the fix value of a dog is quite small and limited. Random vomitting is no fun either. On August 17th, we had to rush him to the ER because he was not moving. The flavored, chewable tablets were consumed . The only thought in my head was to get home and give it to my puppy who has had few fleas, but many itching problems. Hoping you are the lucky ones!! This is lethal medication for dogs and should be taken off the market now. Come to find out Akita blood platelets can explode in storage causing hi readings. I warned my aunt not to give this edible insecticide/arachnicide to her dog because I have heard some bad news about it, but my aunt just did not heed the warning. best of luck to all whose furry ones have gotten sick from this and as well hugs to those who lost their beloved pets. Has odd agitated swallowing when not eating anything. Doubtful our dog will be given Simparica again. It was 11:30 pm . I'm so sorry. The vet said not to give it. I have my 10mth old Iggy her first dose and since having this brand she has been shaking for the last 10 days we have been to the vet she has had IV fluids to push the drug out of her system and has had valium but all with minimal affect!!! Simparico Trio, will not be given to my dog ever again. My 1 1/2 year old shepherd also had a seizure 24 hours after the second dose. So sorry you are having to go through this! The simparica pushed his body into an Addison's Crisis - his body was literally shutting down. Vet said "cant be Simparica because he had 9 days ago". My 11 year old mini Aussie has been taking Simparica 1.5 years. . I just gave him heartgard and nexgard about 2 weeks with no issues. Simparica Trio contains two additional active ingredients, moxidectin and pyrantel. Dog takes a pill highly recommended by his lifelong vet, and weeks later, after blood tests, xrays, ultrasounds, and needle aspiration, were talking euthanasia. Im wondering if anyone else has seen these types of symptoms. Update June 7th. Did the tremors ever stop? It seems to coincide with the monthly dosage. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). I will NEVER give this drug to my dogs! All content contained in this article is sourced from public sources or the manufacturer. They must get some kind of monetary bonus for only selling Simparica. Which Type of Dog Fence Is Right For Your Pet? . Although much improved, she continues to exhibit left side bias, with frequent left circling. I only stumbled on the side effects of this drug via a post on a Spinone group. Went to a different vet, within minutes he found a large mass on my Poms abdomen. In very rare instances, mild side effects and irritations can occur for a short period of time. He drank not crazy about dog food . Hi, Im having similar issues. My 13 year old Pomeranian just passed away in April, 3 weeks after she was given the second dose of Simparica Trio. It is important to work with your veterinarian to ensure the best flea/tick and heartworm prevention plan for your pets specific needs. Things like: Bloody Diarrhea In a margin of safety study, Simparica was administered orally to 8-week old Beagle puppies at doses of 0, 1, 3, and 5 times the maximum exposure dose of 4 mg/kg at 28-day intervals for 10 doses. Gave our Bloodhound Simparico Trip on Tuesday on Thursday he got extremely thirsty and was peeing everywhere from drinking so much water. Conclusion Side-Effects Of Simparica Trio Tablets There are some mild side effects like Vomiting Diarrhea Loss of appetite Dog owners should be aware that these tablets are not suitable for all dogs. She had terrible watery diarrhea and is not interested in eating. Poor dog prob thinks HE did something wrong. You ask why they are giving this poison to our furbabies, it's easy. I PRAY that our baby is okay with this second dose. Today March 20 (8 week old) I get a message saying the puppy ate one of these pills that was for the bigger dog she already owned. Getting him to go out was nearly impossible. Read the package insert and it does list tremors and seizures as a side effect. I fell like hes dying right before my hands. Never any issues with bravecto so we'll return to that medication. I hope it is taken off the market and request that anyone on this thread with a pet who has suffered due to this drug goes to this link from the FDA to officially report their pet's adverse side effects: https://www.fda.gov/animal-veterinary/report-problem/how-report-animal-drug-side-effects-and-product-problems. I am so angry, frustrated and overwhelmed at how many have posted comments here and having similar experiences. I gave my 1 year old collie cross Simparica flea and tick medication. He has been drinking more water then usual. The ONLY thing that could cause such a huge change in behavior and personality had to be giving him the Simparico Trio the previous week. I have a chihuahua/miniature pincher mix dog thats 9 yrs. Overly anxious. Hi there, my dog has been taking simparica trio for two months. . This is taken from the article printed above all these comments "Simparica works by impacting the nervous system of invertebrates such as fleas and ticks. This is happening now and she is still nowhere near 100% but I am hopeful that she will eventually fully recover. Were now into day 2 no changes except add a continuous walking into the next room turn around come back sit down just to repeat several more times. I will use Sentinel and Pet Armor on her as this is what I have always gjven my dogs with no problems. Its been 3 months and she continues to have them. My husband said that he felt like it would just make his coat shiny. I've had to syringe water in his mouth. She has been taking the medicine since she was 6 months and she has gotten bigger so her dosage was increased. RELATED: What You Need to Know About the Lyme Vaccine for Dogs. I can not find any information on a delayed reaction AND my Vet just discredits that its the Simparica because my dog goes to Daycare and could be exposed to other mystery things. Ive read these stories and am also disgusted. Vet says not to go back to Any brand oral flea/tick meds, so well be using Frontline drops on her shoulders from now on. My dog is having the same issues. Oh how I wish I had know the side effects of this medicine I would never haven given it to her.. the company that makes this poison should be sued. She spent 4 nights at the University of Auburn emergency room and vet clinic. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a . The vet recognized immediately that she was in severe neurogical distress. And im so mad that my vet didn't inform me of the side effects and im so mad I didn't research it myself. Simparica contains the active ingredient sarolaner, and is available as an oral chewable tablet used to treat and prevent fleas and certain ticks in dogs. The FDA considers products in the isoxazoline class to be safe and effective for dogs and cats but is providing this information so that pet owners and veterinarians can take it into consideration when choosing flea and tick products for their pets. Other signs may include: Lethargy Loss of appetite My dog died from it after one dose within 24 hours. This should be taken off the market-it's just a BIG pharmaceutical moneymaker at the expense of animals and their unsuspecting owners. What kind of supplements are you giving her? We have never had issues with him peeing in the house - EVER, and he peed in my office. Use a collar or topical if you need to. The diarrhea also went away yesterday evening. We all want to protect our pets from fleas, ticks and the diseases they carry, but some treatments can come with nasty side effects. Compared to other products, the efficiency of this . About 11 months ago our vet recommended Simparica Trio. Coton de Tulear. He is otherwise normal and healthy. All they did was give me a pill in a bag with possible side effects of vomiting or diarrhea. Or has it been too many doses ? I can tell something is off with her I just couldnt figure it out. Consulting vet and will not give Simparica ever again. We may also give additional medications to keep fleas, ticks, and common intestinal parasites away. I will not in good conscience continue to give my three previously healthy dogs anymore Simparica Trio as it causing Gand Mal seizures in my older dog and nausea , vomiting and severe thirst and dehydration. I am extremely upset at myself for letting a similar but very serious threat get to my pup again. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions . Any response from the company? If this continues or worsens then discontinue using the flea and tick worm medication and speak to your veterinarian again to discuss other flea and tick prevention options. I am so sorry to all of you and my heart goes out to you and your babies. He had never pooped in the house and now he does every time he has to be put in his indoor pen for us to leave or sleep. We are closely monitoring him. It all depends, sadly. Cooper.. 8 years old By chatting and providing personal info, you understand . RELATED: Signs Your Dog Might Be Having a Seizure. How is your cockapoo doing now? The prescription-only chewable tablet is given once a month to dogs and puppies eight weeks and older. She had a beautiful coat of fur. Couple of days ago, I took my other doxie (Maddie) into my vet, for shots, he did the heart worm test and recommended Simparica. They immediately denied they were in the wrong for prescribing because any meds can have side effects but Im convinced this medication is poison. He took simparica trio 3 weeks ago and I cant wait until its out of his system! PROS Treats adult fleas and prevents flea and tick infestations Effective against five types of tick Liver flavored tablet FDA Approved CONS Now his tail looks like a rat tail. Later in the fall I noticed some leg tremors when she squatted. I looked up side effects for this drug and was horrified to find that the flea med can cause tremors seizures and worse. Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. My vet recommended Simparica Trio for both my dogs (13 year old healthy Collie mix 7 lb chihuahua mix). Our pups had been on next guard and heart guard with no issues but new vet stopped selling those products so switched to to the simparica trio - gave a dose to our 7 ur old 71 pound blue tick coonhound Frazier and our 10 mo 45 pound labradoodle- Watson. Our vet pushed this new drug for this tick season claiming the drug we used previously they had 11 dogs in the previous year were diagnosed with Lyme disease and they no longer had confidence in that drug. Those jaw spasms have decreased but were pretty alarming in Dec and January. MONEY!!. So bad that the FDA made them put a huge warning now on the package. The vet has not been able to diagnose a cause. So sorry to hear, and good for you in recognizing the problem! The product can be purchased directly from your vet, from your vet's online pharmacy, or through an external online pharmacy with a valid prescription. If this is a long term issue, I doubt they would be willing to cover all visits in the future. Even when asked to go for a car ride he didn't respond. These dog training tips will help you get started. Just gave 3yr old OES first dose yesterday (her half sister got one too) and today she has uncontrolled urination. Her heartbeat was more of a vibration than a beat and the vet wanted her to see a cardiologist. Around 9pm he was barely able to jump up onto the couch and was extremely hesitant to go up the steps. She was riddled with parasites when she was found as a stray, and then treated for heartworm disease just before I adopted her. Anyway, he prescribed him pain relief for 7 days. His motor skills have been affected and hes been losing weight even though he eats heartily. But I have decided not to give the replacement pill today. Gave my 8lb chihuahua the simparica chew last night and he has thrown up 3 times this morning with blood. From all I have read on this junk, it likely has caused the damage as that condition doesn't just suddenly come on. Since she is young, the vet started us with Keppra. I just cross my fingers every day that she will get better after this is out of her system. Vet thinks it may be Addision disease and wants to test for it. Shes not the carefree setter she was prior to this medication. my vet recommended this for both my yorkies. Zoetis.com.au; Privacy Policy This links to a pdf file; Terms of Use This links to a pdf file Company asked us to do diagnostic testing at vet. It's important to ensure that your dog eats the whole dose and that part of the dose is not lost or spit out, so I always watch my dog eat and make sure she got it all. This month 5/1 gave him another dose and here we are 12 days later with diarrhea and no appetite. This is so scary. #JusticeforCassie My thoughts and prayers are with you all as I go through the same thing with my beautiful Cassie girl. I returned that medicine back to the vet and bought Revolution! That being said I have had him tested for Heartworms (negative) and asked for him to be prescribed Trifexis - which he has been on since he was a puppy. Side effects are rare and may include: Neurologic side effects have been seen after using medications in this class of drugs. Vet suggested that I switch to Simparica Trio (he gets a kickback from the manufacturer). Some dogs improve, some don't, not a clear answer why. My dog weighs 60 pounds and was given a dose for dogs up to 88 pounds. This is apparently not true and that's why the article never goes on to explain exactly why it only works on GABA receptors in fleas and ticks yet not affect the GABA receptors in your dog. All the swelling went down immediately and the itching went away too. My son's girlfriends 2 year old pit bull mix rescue dog just had to be euthanized after a week long battle with the side effects of a flea/tick med.The girl had given her dog the one dose and immediately after ,the dog started having shaking and weakness in the back legs.Took her to an emergency vet.Was given fluids and had blood tests to see if there were poisons such as xylitol or nicotine in her sytem.No problems.$900 later..jsu 2-3 hours on fluids she was released with no answers.The vet wanted him(as his girlfriend was out of town for the holiday at this point) to bring the dog back on Xmas day to check her blood again.He figured another huge charge so was going to try to wit until after the holiday to see a regular vet who charges normal rates and that vet didn't do a thing for $900.00.The dog got progressively worse.Couldn't walk ,couldn't eat ,couldn't bark.Eyes were darting from side to side.Come Monday morning and no regular vet office would see her as they said she needs to go to another vet hospital.They wanted 2,600.00 from my son right up front for an overnight stay.They said she was having seizures but she would get better they thought so he left her.The next morning they said she needed more days in the hospital.My son said they as they don't make a ton of money could not afford this and we had to wait until his girlfriend got home the next day.He wanted to take the dog home.They said they would keep the dog for free for 12 hours..Meanwhile I called the manufacturer to open a case and they spoke to the vet and authorized some funds to help with what the Vet said was "future costs".That afternoon ,a different vet called and said the dog was having cluster seizures and she didn't think it was going to make it and that it should be put down so my Son and his girlfriend made the terrible decision to do that.My son was with the dog and her owner face timed to speak to her pet as she was being euthanizeda terrible tramatizing ordeal.Next thing you know,my son gets the ivoice from the Vet and it is over 5,000.00. 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