But in taking them separately, does strontium replace calcium in the bones? After a month or two using the nebulizer, many of our patients have been able to just take NAC orally; they are that much better! Epub 2016 Oct 21. In fact, 99% of the total amount of strontium in the body is found in bone, a trait it shares with calcium. So, they were looking at short term (in comparison to the rest of a postmenopausal womans life span) outcomes. If you are taking 680 mg/d, cut this back to 340 mg/d; the latest research indicates you will still receive significant benefit from this lower dosage. excellent responses to queries i would like to know in what dosages do one has to So, amount of calcium provided by AlgaeCal Plus is 720 mg/day, plus you need to look at your diet to see how much calcium you are typically getting from the foods you eat. Replenish all the nutrients your bones start losing after age 40 and then some. Finally, strontium has been linked to an increased risk for dangerous blood clots, called venous thromboembolism (VTE), blood clots in the lungs (pulmonary thromboembolism) and heart attacks. Even taking 3 tablets only increases the calcium intake to 540 mg. In the U.S., Your Bones was approved by our library book review system and is available in our public libraries as well. I read all your information to other women and I try to learn what is best for me too. This mineral increases our ability to absorb and deposit calcium in our bones. Hi Todd, However, discrepancy was also observed for several other transporters (such as MDR1, MRP3, GLUT1, and GLUT3) in both the duodenum and colon of human and rat. Besides, strontium has been shown to reduce fracture risk independent of bone density. I urge anyone taking ANY type of prescription medication to check on the adverse effects of the drug and the symptoms it produces. MANY people are deficient in iodine for a variety of reasons I summarized in a 2 part review paper I wrote on iodine for Longevity Medicine Review (here is a link to Part I http://www.lmreview.com/articles/view/iodine-the-next-vitamin-d-part-I/) As I expect you know, our bodies cannot produce thyroid hormone without sufficient iodine (T4 requires 4 iodine molecules, T3 requires 3 of them). I had been rebuilding bone, but slowly. Many thanks Lara and any suggestions would be appreciated. is he board certified, etc.? If your current level actually is too high, then cut your dosage in half. The scientific facts are so different from these assertions, its unclear why they publish such misinformation. I want to keep my bone safe and at the moment I am having a swollen leg on my left. . Still take at least 5 drops a day. Heres my reply: Could you please comment about this article re: strontium ranelate. In addition I take 5 mg of Vitamin K4 (menatetrenone). Will the strontium interfere with these medications? PMID: 20965537, Ferreri SL, Talish R, Trandafir T, Qin YX. The new-forming bone in the trabecular part of your bones is far more active and incorporates more strontium ions than the cortical bone. Hi smlhealth, Just finished your book-absolutely brilliant. After reading these papers (which were published in the peer-reivewed medical literature and are accessible on PubMed), I decided to try AlgaeCal. Women using HRT were shown to have higher BMD and also greater risk of breast cancer. I take a PPI for stomach issues. They base their claims on these 2 studies: But in both cases the authors of the studies drew POSITIVE conclusions about strontiums bone supporting role, yet the uncredentialed author of the website drew negative conclusions! Re your vitamin D levels, which your last blood test showed were too low (you want to be between 60-80 ng/mL), since you are lucky enough to be living in the Phoenix area, if you are not already doing this please get outside for at least a half hour sometime between 12pm and 2pm and get some sunshine on your skin (no sunscreen!). Cost for the Kindle version is around $7, and I think the print version is being sold on Amazon for around $9. No adverse effects. In the 2 g/d group, there was a significant increase in serum levels of bone alkaline phosphatase, whereas urinary excretion of cross-linked N-telopeptide, a marker of bone resorption, was lower with SR than with placebo. It's been compared to calcium in its bone-boosting abilities. From what you write, it is apparent that you are not meeting your needs for magnesium, unless you are eating a diet VERY rich in magnesium AND your digestion and absorption are excellent. Am I understanding the new bone/old bone terminology correctly here. The stomach is a very acidic environment, but after eating, your stomach becomes less acidic. : i would like to know in what dosages do one has to take strontium citrate and calcium ect.. i changed to strontium citrate [ costs about a third of ranelate]about 3 months ago after being on ranelate for 5years.. i had a bmd in january and it showed a small improvement which i am grateful for i`m 63yrs and excited to see next year`s results i am changing my calcium from Biogen Calmag Max Absorption[with120ug K2 ect to Real Thing Bone Revolution an organic sea veg calsium mineral mix these products we get in south africa.. further i take everthing in stride,,, had a couple of falls with no fractures perhaps i`m just lucky referring to other letters of people having a lot of fractures nice writing to you forgive the errors, english is my second language regards.. patricia. We recommend speaking with your doctor to see if Strontium Boost is right for you. In conclusion, the different studies performed on bone samples from monkeys and humans treated with various doses of SR showed that Sr was heterogeneously distributed between new and old bone but in a dose-dependent manner without alteration of the crystal characteristics and the degree of mineralization of bone tissue, even after long-term administration of often high doses of SR (the highest therapeutic dose used in humans is 4-fold lower than the lowest experimental dose administered to monkeys). I will be getting about 100 mg of K2 (MK7) from my other supplements. PMID: 23877652 I heard it was not good to take it so long. You will not need your former calcium supplement. Hi Dennis, Lara: Hi Lara, you have mentioned your improved BMD DEXA results after taking Algaecal products including strontium. Shouldnt the label reflect the actual percentage? Are you taking any prescription or over-the-counter drugs? (Many impair digestion, not just the acid blockers.) strontium supplement. After about 2 weeks I noticed extreme fatigue. Strontium is a chemical element that naturally found in our body in small amounts. Any issues? I believe it is a foundational health supplement for everyone not only postmenopausal women. Of course, happy to do what I can to be of help, and yes, each of us is our own best advocate, although you are definitely in good hands if you are working with a fully IFM certified functional medicine physician and nutritionist. The decline in DHEA, which is produced by our adrenals & thus not related to menopause at all, can start as early as the late 20s, and research has proven that our levels of DHEA correlate with BMD in both pre- and postmenopausal women. If so, the label seems to indicate there are 680 mg of strontium in 2 capsules (and a higher amount of the strontium citrate compound). In conclusion, SR therapy increased vertebral BMD and reduced the incidence of vertebral fractures. But again, this is a trade-off that has to be weighed based on how acute your infection is and how quickly you need that doxycycline to get into your body. Last summer (July 2011), I switched to AlgaeCal Plus as my source of supplemental calcium and to Strontium Boost for my strontium supplement. Ill quote them: strontium may interact with estrogens to promote carcinogenesis among young [premenopausal] women, because young women have more estrogens and estrogen receptors., Chen LJ, Tang LY, He JR, et al. I mentioned this earlier, what are your thoughts on the following statement given in Lis thesis paper (cited above): Interestingly, according to one study, 170 mg of strontium per day was more effective than 680 mg per day for reducing fracture risk (Meunier et al., 2002), which raises the possibility that even lower doses might be as effective as, or more effective than, the dosages that have been studied.. You might check with Martha Grout, MD. Stay well! Within 3 hours, you will have digested the yogurt and absorbed the calcium in it. Osteoid: Osteoblasts secrete osteoid, the unmineralized portion of the bone matrix, as the first step in their bone building process. I have been diagnoised with Osteoprosis. After reading some comments about citrates, some years ago I too Calcium Citrate and ended up with awful heart palpitations and thumping (the only way I know to describe it). If this happens on an empty stomach with no food present to disperse the highly concentrated vitamins and minerals, the result can be nausea. AlgaeCal is ecologically Harvested by hand / Aquamin is harvested via dredging, which silts flora and fauna The derivation of this figure has not been published, but the results shown in Table 1 suggest that it is an average of the figures of 41% and 66% derived from the SOTI and STRATOS studies assuming a BSC (bone strontium content) ratio of Rspine 50.61. So, somewhere between 41-66% is overestimation AND that also means that somewhere between 34-59% is actual improvement in BMD. A previously developed in vivo X-ray fluorescence (IVXRF) I-125 based system was used to measure bone strontium levels non-invasively in an osteoporotic female volunteer. You may need to take iron with a small amount of food to avoid this problem. Actually, the K1 will have no impact on Gla protein activation it will be used for clotting factors and also has anti-inflammatory effects (so good to help prevent excessive activation of osteoclasts, which is triggered by chronic inflammation). I also e-mailed Meunier and asked if his cited study (or any he knew of) suggested 170 mg to be more effective than 680 mgas the above people are citing him as demonstrating that. Abstract I also take 4 capsules of the Algaecal Plus daily(lunch/dinner). I know that I am my own best advocate when it comes to my health and appreciate your willingness to help those of us who are trying to educate ourselves. Cortical bone is their hard, outer layer. Again, Lara sorry for giving you a headache with this strontium dosage, and thanks so much for your help in investigating this matter with me, if any of those authors emails me back I will let you know. Could you let me know what research you have seen suggesting effects on thyroid at 41 mg/day? (1) Key point in the COMB paper is the where possible in this quote from the paper:Patients were also instructed to commence and maintain a regimen of daily impact exercises such as jumping jacks or skipping where possible as impact has been associated with prevention of bone density loss. This is what I began doing for myself several years ago now after I read and reported in this post on AlgaeCal.com that a half-dose was effective for maintenance. The results confirm both theoretically and experimentally that the effect of bone strontium on BMD measurements is different for different DXA systems. https://www.ncbi.nlm.nih.gov/pubmed/20699129. Again, thanks for all your prompt responses and your amazing insight! If so, then I think your plan is excellent. Symptoms of DRESS syndrome typically begin 1-8 weeks after exposure to the medication. Also, you want to consume approximately twice as much calcium (from food and supplements) as strontium. And stay gloriously well, Subjects were 160 postmenopausal women, mean age 73 years, with a hip BMD value of more than 2 standard deviations below the reference value, so clearly well into the osteopenic / osteoporotic range. HERE is a link to Mayo Clinics discussion of causes of hair loss. It was impossible to calculate the elemental dosage because they didnt provide the molar-mas of the compound. In contrast, as I stated in the above blog (and backed up with studies conducted over the last 100 yearsthe citations for which are provided in the references) , the natural form of strontium available as a supplement, strontium citrate, has never been shown to produce any of the side effects seen with strontium ranelate. So I need all the help I can get now God Bless you .Audra, Sorry, I forgot to say anything about genistein I would recommend eating more soyfoods (organic definitely, you do NOT want GMO soyor GMO anything else, for that matter). Moderate correlation (with r(2) > 0.56) was also found for the expression levels of transporters in the duodenum of human and rat, which provides the molecular mechanisms for the similarity and correlation of drug absorption between two species. PMID: ), then check the references he provides (probably none) to ensure the papers he is basing his claims upon actually say what he is using them to assert. Here are the citations for the studies upon which the COMB researchers based the studys exercise recommendations: Heres a link to my talk on TBS: https://blog.algaecal.com/how-to-analyze-your-dexa-results-for-bone-quality/ The really good news is that your DXA images can be used to calculate your TBS, so please request that this be done for you when you go in for your next DXA. Interestingly, the women taking 340 mg/d had comparable or better results than the woman taking 680mg/d an outcome the researchers thought might have been due to the fact that the women taking 340 mg/d took their strontium at night (when bone remodeling is more active), while the woman taking 680 mg/d took her strontium supplement during the day. Mary. As I am still osteopenic (though just barely so now), I continue to take the full 680 mg dose. Thank you. Thanks again. If you are not consuming any dairy products, your diet is most likely providing very little if any vitamin K2, for which the best source in the western diet is cheese, particularly Jarlsberg and Emmenthaler. This allows you to take a smaller dose than you might with synthetic forms of calcium for easy digestion. How to boost your ability to absorb strontium and get the most from your strontium supplement. In the section above with the subhead, Adverse Side-effects Are Seen ONLY with Strontium Ranelate Natural Strontium Salts, Like Strontium Citrate are Safe, I explain that the latest research confirms that strontium ranelate increases risk for VTE. have soya yogurts [ Ive suffered from 1/2 hourly hot flushes for 5 years]. Raw vegetables This one is specially for those who are diet conscious and believe that salads are great anytime of the day. Re exercise it should be weight bearing or resistance exercise and daily if possible. You recently stated the following: Strontium, like calcium, incorporates into both trabecular and cortical bone, but strontium deposits almost entirely into newly forming trabecular bone, with one strontium ion substituting for less than one calcium ion out of 10 in the bone matrix. I would be really interested to know 1) the exact amount that ends up as cortical bone and its incidence in making it weaker 2) to view the studies highlighting the assimilation of Strontium as trabecular bone. Sorry to hear youre experiencing nausea not fun! Since being diagnosed with osteoporosis [-3.5 spine, -2.7 L. femoral neck] and Osteopenia [2.1 L. hip, 2.2 Rt hip. However, unless these women were consistently taking their 680 mg strontium supplements with meals providing comparably large doses of calcium an unlikely situation they would receive some benefit from the strontium. How old are you? I have not seen this in any of the peer-reviewed published medical research, and I have now looked at all the major papers on strontium published in the last 100 years. 2. You should take it with water 30 minutes before eating breakfast. Hope this helps. I attempted to send this email last evening but I dont think it sent. I am wondering what to do? Great to hear that you are definitely in normal range or in the one area you mention having a T score of -0.6, are barely osteopenic! Heartburn, stomach pain, or diarrhea; back, muscle, or joint pain; a headache, and flu-like symptoms are the most common side effects. In vitro chemical experiments have also shown that Ca21 may be exchanged by Sr21 in synthetic calcium hydroxyapatite.. Mesenchymal stem cells: Exposure to strontium promotes these precursor cells development into osteoblasts rather than into adipocytes (fat cells) A more accurate answer depends on the drugs you are taking and your medical conditions. If you like, you can provide them with THIS handy information sheet on Strontium Boost at your next visit. The reason I take it at night is to ensure that nothing is going to interfere with the absorption. The use of strontium ranelate has never been approved in the U.S. and is now significantly restricted in Europe, while strontium citrate is freely available. Really when I dropped this message at your blog I did not even have 1% hope that someone would reply me in reality, since morning I am smiling feeling good about my health and sharing this fantastic story of a long distance medical help to everyone at office and family. My question is, are there any negative side effects of taking the strontium citrate and calcium around the same time? I was attempting to simplify but see that just increases potential for confusion. I went with my BMD report to a bone doctor which prescribed me with Strontium Renalate suspension. I began taking AlgaeCal after coming across the research 2 in vitro trials and 2 human trials conducted on their products and published in the peer-reviewed medical literature about 2 years ago now. I take Symbicort 160 4xday, am working hard on trying to get it down to 160 2x day with 80 2x a day. That said, with your levels being in the 80s, the full dose of Strontium Boost should be just fine, however we would still recommend checking this over with your doctor, and continue to monitor these levels for any changes. Also, your answer gives me peace of mind in deciding to half my dose of strontium citrate. Your thoughts on this would be most appreciated. Regarding maintaining 2:1 balance with calcium, AlgaeCal Plus is giving you 720 mg of calcium, an amount more than sufficient to maintain the 2:1 balance between calcium and strontium recommended to ensure safe, effective use of strontium. Detailed analysis indicates that many transporters (such as PepT1, SGLT-1, GLUT5, MRP2, NT2, and high affinity glutamate transporter) share similar expression levels in both human and rat with regional dependent expression patterns, which have high expression in the small intestine and low expression in the colon. What I can offer you are some suggestions in response to what I see in your note to me this will sound like an advertisement, but I urge you to get a copy of Your Bones and read it! Although you only need 3 milligrams of boron daily, this is a trace mineral that is difficult to get even in that small amount from the diet. 2004 Sep;35(3):583-8. Take three (3) capsules once daily, or as recommended by a healthcare practitioner. Ranelic acid is the synthetic compound used to create the unnatural strontium salt, strontium ranelate. I have plaque in my carotid arteries, 20-40% range, I started getting the MK7 with the Algae-Cal, but was already taking some MK-4 drops (5-8 a day). Unfortunately, we arent familiar with the safety of canned sardines for dogs. Strontium citrate is 31% elemental strontium and 69% citrate, so 2 capsules provide 236 mg of elemental strontium + 440 mg of citrate. What all this means is that infection with Clostridia is not at all uncommon and in people who are infected with Clostridia, consuming citrate turns up the activity of this pathogenic bacteria, which produces and releases some really toxic stuff that can cause all the symptoms you mention. Venous thromboembolism (VTE) refers to life-threatening blood clots in deep veins. I found a number of recent papers. I have a green smoothie at least 5 days a week with collards or kale. Hi Lara Hi Barbara, Thus, I am unable to read the paper in which 170 mg of strontium is said to be more effective, so I do not know what was done and cannot give you more helpful feedback on this. Im not sure where I should look for a response. Zenda S, Nakagami Y, Toshima M, et al. Futhermore if bones follow the pattern of teeth ,then according to the study, An association between strontium in drinking water supplies and low caries prevalence in man, maybe I should take 5-10 mg/day . 2011 May 1;48(5):1095-102. 2002-2023 AlgaeCal. Any thought?? We dont have it yet though. With my steroid issues, do you think the strontium is my best hope. (2) The first study cited by Genuis et al. PMID: 26910208 Ive been getting abdominal discomfort, bloating and cramping. Please dont apologize for asking such interesting questions, especially since the answers to them could have very significant practical relevance for human health. I read in the discussion that a GFR of 50 or less would indicate that I should not take Strontium. Older adults often have multiple medical conditions and may take many medicines, which puts them at additional risk for negative side effects. I recently had a DEXA scan which showed some improvement in my bone density. Useful information. I no longer have this problem because I treated the reasons for this pain primarily by increasing my intake of anti-inflammatory omega-3s. Its going to take some work I very much hope you will read the articles and Your Bones for solid, research-backed information and get the appropriate tests run (I also discuss a number of tests in the bookwhen you read the sections in which they are mentioned, you will know if they are ones you should consider), but you absolutely can figure out what YOU need. I do this by taking Triple Power, which in addition to EPA/DHA, also contains two very powerful but safe anti-inflammatory agents: curcumin and astaxanthin. It can be found in soil and seawater, and it's actually used as a supplemental treatment for osteoporosis and other bone diseases. The information on the strontium/thyroid is found in the Lis thesis paper cited above. Supplemental strontium should be avoided in individuals with a creatinine clearance less than 50 mL/minute or who are on dialysis. You just need to take it at a different time of day from when you take calcium (as I have written in the blog and in response to questions here, calcium and strontium compete for absorption, and calcium is better absorbed, so if you take them at the same time, you will receive less benefit from the strontium.) Unlike other meals, we almost always eat breakfast on a completely empty stomach. Otherwise, the medication may lose its effect. I would be interested to learn of any further research on Lactoferrin and its positive effects on bone building. The strontium and increase in thyroid weight, that I had reference to, can be found in the thesis paper (cited above) in one of the literature review portions. https://www.facebook.com/lara.pizzorno.5/videos/10218830498263978/. In addition, I am an LMT and am currently finishing my STOTT Pilates certifications. Thus, for 71% of the participants in this study, a short daily period of exercise, a few minutes of which was high impact exercise, was a reasonable and safe recommendation. For most people, 3 hours or even 2 hours will be sufficient. Initially, it did not appear that my first message went through. Three women in the exercise group experienced musculoskeletal problems that required minor modifications in their training regimen. Epub 2010 Sep 26. In fact, in the one and only study on PubMed I could find suggesing even a remote connection between estrogen and strontium a rat study involving ovariectomized rats (an animal model for human postmenopausal women) that were given estrogen, the rats metabolism of strontium normalized. I have learned quite a bit about strontium citrate, including how/when to take it. Milk, calcium and antacids should not be taken at the same time as iron supplements. coughing up blood or vomit that looks like coffee grounds. If you take AlgaeCal Plus, the full daily dosage will be giving you 90 mcg of K2 (MK-7). We look forward to hearing from you! Be well! so interested to read you and your incredible store of information especially about Strontium Citrate. AlgaeCal Plus provides 720 mg of calcium per day (4 capsules 2 AM and 2 PM) and your diet should be giving you the remaining 380 mg of calcium you need to reach a daily intake of 1,200 mg/day. YOU are typically getting from your diet. Will this affect the absorption of the bone building products? So, now I will take it on an empty stomach. Has anything else diet or medications or an infection, like the flu changed recently? (Having the flu can depress your stomachs ability to secrete stomach acid for a bit, so can antibiotics if youve been told to take them for any reason.) Every woman in my family whom I know about for many generations back died from osteoporosis I am the poster child for risk for this disease, but have managed to beat it by learning what my bones need and supplying it. Specifically based on strontium levels and safety. Im going to go and eat some now as I am determined to keep my bones strong!!! However, my confusion now lies in the amount of calcium in the two tablets of AlgaeCal Plus. Consequently, they have a very large interface with extracellular fluids, and numerous interactions between ions from the extracellular fluid and ions constituting apatite crystals are thus possible. Im taking off a good part of today to be in the kitchen cooking pumpkins to make soup and custards, and making rice stuffing (we are gluten-free folks) to fill a kamboucha squash that will be our centerpiece this year. Recent studies have emphasized the . Strontium increases our absorption of calcium yes, calcium! The primary efficacy endpoint was lumbar bone mineral density (BMD), assessed by dual-energy x-ray absorptiometry. I am on your bone building plan from your book and taking Algae Cal and Strontium. But, meantime, here are my thoughts in reply to your comment. (also, my blood pressure was rising significantly enough that my Dr put me on blood pressure meds), Hi Pam, You took it with supplements. 1, pp. AlgaeCal 2 had a positive MAPC of +2.79%. J Bone Miner Res 2000;15:1526-36.) Ive written up all this research for inclusion in the 2nd edition of my book, Your Bones, which will be out in March 2013 its very interesting! Were so sorry to hear that you have been experiencing abdominal discomfort, bloating, and cramping this certainly could be due to the citrate if you have an infection with any species of the pathogenic bacteria Clostridia. The ability of patients with CKD to clear strontium (and everything else requiring elimination in urine) is compromised. A little daily high impact exercise by women in the mildly osteopenic range should be safe and may go a long way towards maintaining healthier bones. This being said we must ALWAYS trust our own bodies when our personal results dont match up with the research no matter how august and respected the medical journals or how many studies have been published showing something that our own unique body is not agreeing with! I hope this information helps it is ALL fully referenced by articles in the PubMed listed journals all the references will appear in the article with links to the papers once published. I follow the Bresdan protocol, eat a whole foods Keto diet, am gluten,dairy,soy and sugar free, walk 3 miles daily, and eat organic 90% of the time. I wore a Holter monitor for 24 hours but the doc didnt find an issues. Hi John, And more strontium in your bone causes the DEXA to overstate your bone density increase. 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